Michael R Zalutsky Selected Research

ErbB Receptors (EGF Receptor)

1/2022	Low-level whole-brain radiation enhances theranostic potential of single-domain antibody fragments for human epidermal growth factor receptor type 2 (HER2)-positive brain metastases.
1/2019	Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[18F]Fluoronicotinate Resulting in High Tumor-to-Kidney Ratios.
1/2017	Preparation, cytotoxicity, and in vivo antitumor efficacy of 111In-labeled modular nanotransporters.
4/2016	Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.
4/2014	Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling.
10/2012	Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I.
1/2012	Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors.
1/2012	Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery.
10/2010	Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.
2/2009	Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands.

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Michael R Zalutsky Research Topics

Disease

88	Neoplasms (Cancer) 04/2024 - 01/2002
24	Glioma (Gliomas) 07/2018 - 01/2002
20	Breast Neoplasms (Breast Cancer) 01/2023 - 11/2003
17	Brain Neoplasms (Brain Tumor) 01/2022 - 10/2003
9	Prostatic Neoplasms (Prostate Cancer) 04/2024 - 10/2014
8	Glioblastoma (Glioblastoma Multiforme) 04/2016 - 11/2002
6	Carcinoma (Carcinomatosis) 01/2022 - 11/2005
4	Medulloblastoma 01/2010 - 05/2003
4	Neuroblastoma 11/2007 - 09/2004
3	Neoplasm Metastasis (Metastasis) 03/2021 - 10/2011
3	Neuroendocrine Tumors (Neuroendocrine Tumor) 08/2015 - 04/2004
3	Hypoxia (Hypoxemia) 08/2013 - 02/2011
2	Melanoma (Melanoma, Malignant) 01/2017 - 01/2012
2	Neoplasm Micrometastasis 10/2016 - 09/2008
1	Osteosarcoma (Osteogenic Sarcoma) 01/2022
1	Body Weight (Weight, Body) 10/2021

Drug/Important Bio-Agent (IBA)

28	Monoclonal AntibodiesIBA 09/2020 - 01/2002
21	N-succinimidyl 4-guanidinomethyl-3-iodobenzoateIBA 04/2024 - 01/2002
14	ErbB Receptors (EGF Receptor)IBA 01/2022 - 01/2002
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2006
12	Single-Domain AntibodiesIBA 04/2024 - 01/2013
10	Radioisotopes (Radionuclides)IBA 07/2023 - 01/2008
10	Trastuzumab (Herceptin)FDA Link 10/2019 - 11/2003
9	AntigensIBA 01/2022 - 09/2004
9	Peptides (Polypeptides)IBA 01/2022 - 05/2003
7	RadiopharmaceuticalsIBA 04/2024 - 08/2004
7	epidermal growth factor receptor VIIIIBA 04/2016 - 01/2002
7	3-Iodobenzylguanidine (Iobenguane)IBA 08/2015 - 04/2004
7	1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycolurilIBA 01/2012 - 03/2003
5	AntibodiesIBA 01/2022 - 08/2010
5	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 08/2015 - 11/2005
5	TenascinIBA 05/2007 - 11/2002
4	EnzymesIBA 07/2018 - 11/2009
3	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 11/2022 - 01/2010
3	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 07/2018 - 08/2016
3	Immunotoxins (Immunotoxin)IBA 04/2016 - 06/2008
3	Therapeutic UsesIBA 08/2013 - 08/2009
3	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2010 - 05/2003
3	Octreotide (Sandostatin)FDA LinkGeneric 11/2007 - 05/2003
2	Human Serum Albumin FDA LinkGeneric 11/2022 - 09/2011
2	Biomarkers (Surrogate Marker)IBA 10/2020 - 08/2013
2	GoldIBA 07/2019 - 01/2015
2	1,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA 12/2018 - 01/2017
2	EpitopesIBA 12/2017 - 08/2010
2	Amino Acid Transport Systems (Amino Acid Transporter)IBA 01/2017 - 10/2011
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2017 - 01/2015
2	HydrogelsIBA 04/2016 - 07/2012
2	Iodine-125IBA 02/2016 - 01/2006
2	Epidermal Growth Factor (EGF)IBA 01/2012 - 01/2012
2	DNA alkyltransferaseIBA 01/2011 - 04/2006
2	Alkylating AgentsIBA 01/2011 - 04/2006
2	Single-Chain AntibodiesIBA 08/2010 - 01/2006
2	Elastin-Like PolypeptidesIBA 05/2010 - 11/2006
2	Glucose (Dextrose)FDA LinkGeneric 01/2010 - 05/2003
2	somatostatin receptor 2IBA 12/2009 - 05/2003
2	Somatostatin Receptors (Somatostatin Receptor)IBA 11/2007 - 12/2004
2	N-acetyltalosaminuronic acid (NAT)IBA 06/2006 - 11/2005
2	sodium-iodide symporter (sodium iodide symporter)IBA 11/2003 - 10/2002
1	MethyltransferasesIBA 07/2023
1	DNA (Deoxyribonucleic Acid)IBA 07/2023
1	Transcription Factors (Transcription Factor)IBA 07/2023
1	maleimideIBA 11/2022
1	Cysteine (L-Cysteine)FDA Link 11/2022
1	peptide IIBA 01/2022
1	RG7388IBA 10/2021
1	6- methoxy- 1- (naphthalen- 1- yl)- 9H- pyrido(3,4- b)indoleIBA 04/2021
1	Tumor Suppressor Protein p53IBA 04/2021
1	LigandsIBA 03/2021
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2020
1	Radiation-Sensitizing AgentsIBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	IsotopesIBA 01/2020
1	human ERBB2 proteinIBA 10/2019
1	Radium-223IBA 01/2019
1	Fluorine-18IBA 01/2019
1	Alkaline PhosphataseIBA 01/2019
1	AGI-5198IBA 01/2018
1	pertuzumabIBA 12/2017
1	Leucine (L-Leucine)FDA Link 01/2017
1	MelanocortinsIBA 01/2017
1	Essential Amino AcidsIBA 01/2017
1	Urea (Carbamide)FDA LinkGeneric 10/2016
1	LuciferasesIBA 10/2016
1	SulfonamidesIBA 08/2016
1	alpha-hydroxyglutarateIBA 08/2016
1	TitaniumIBA 04/2016
1	D2C7-(scdsFv)-PE38KDELIBA 04/2016
1	Antineoplastic Agents (Antineoplastics)IBA 02/2016

Therapy/Procedure

34	Therapeutics 07/2023 - 11/2002
16	Radiotherapy 01/2022 - 05/2003
6	Radioimmunotherapy 02/2009 - 01/2005
5	Brachytherapy 01/2017 - 01/2006
5	Drug Therapy (Chemotherapy) 01/2011 - 06/2005
4	Precision Medicine 04/2024 - 01/2015
4	Injections 04/2016 - 06/2005
3	Immunotherapy 08/2010 - 09/2004
2	Castration 01/2019 - 07/2018
2	Intravenous Administration 12/2017 - 09/2010
1	Cranial Irradiation 01/2022
1	Photochemotherapy (Photodynamic Therapy) 02/2016